Chemotherapy May Lead to Mitochondrial Dysfunction in Skeletal Muscle

https://www.newswise.com/articles/chemotherapy-may-lead-to-mitochondrial-dysfunction-in-skeletal-muscle

Rockville, Md. (October 4, 2018)—Chemotherapy drugs to treat breast cancer may promote muscle mitochondrial dysfunction, according to new research. Dysfunctional mitochondria, the energy centers of the cells, may contribute to fatigue and weakness that some people with breast cancer experience through the course of disease treatment. The study is published ahead of print in the American Journal of Physiology—Cell Physiology.
Breast cancer, the most commonly diagnosed cancer in the U.S., has been considered one of the less-damaging cancers in terms of severe muscle wasting and weight loss (cachexia). However, some people with breast cancer may also suffer from muscle loss and fatigue that limits their daily activities. There is limited research on the effect of breast cancer and its treatments on the muscles in human patients.

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